MPTH-40. COPY NUMBER ALTERATIONS IN PLEOMORPHIC XANTHOASTROCYTOMA AND ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA: CHARACTERIZATION OF 40 CASES BY SNP ARRAY
نویسندگان
چکیده
منابع مشابه
Pleomorphic xanthoastrocytoma.
We report two cases of pleomorphic astrocytoma, a rare primary brain tumor with an unusually good prognosis. These lesions typically are peripherally located, partially cystic, temporal lobe masses. Dural attachment is frequent, calcifications are not. Angiography usually shows a hypovascular mass, although blood supply from the external carotid artery may be seen.
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Pleomorphic xanthoastrocytoma (PXA) is usually a low grade astrocytic tumor. However, some cases show significant mitotic activity (5 or more mitosis per 10 High Power Field) and/or necrosis. These tumors are described as pleomorphic xanthoastrocytomas with anaplastic features and display increased risk of recurrence. We aimed to evaluate histopathological, immunohistochemical and molecular fea...
متن کاملBRAF/MEK double blockade in refractory anaplastic pleomorphic xanthoastrocytoma
A 32-year-old woman was diagnosed in February 2012 with a grade II pleomorphic xanthoastrocytoma (PXA) of the right parietal lobe. A complete excision was performed, followed by tumor bed irradiation (66 Gy). A local relapse occurred in September 2013, for which a partial resection was performed, confirming a grade II PXA. Immunohistochemical analysis indicated the presence of a BRAFV600E mutat...
متن کاملPleomorphic Xanthoastrocytoma with Anaplastic Features: Retrospective Case Series.
OBJECTIVE Pleomorphic xanthoastrocytoma (PXA) is a unique meningocerebral glioma with a relatively favorable prognosis. PXA also possesses a variant with anaplastic features (aPXA), which is associated with poor outcomes. To date, few studies have examined the clinicopathologic importance of these anaplastic features. METHODS From 1999-2012, 8 patients with aPXA were treated at the University...
متن کاملPleomorphic xanthoastrocytoma: an atypical astrocytoma.
Pleomorphic xanthoastrocytoma (PXA) is rare primary neoplasm of brain. Despite its pleomorphic appearance, it has a relatively good prognosis. We report a case of biopsy proven pleomorphic xanthoastrocytoma in a young male who presented with visual and sensory symptoms, classical neuroimaging findings and showed remarkable recovery, post surgery. We have also reviewed recent literature focusing...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2016
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/now212.477